The house dust mite (HDM)
Kind permission of London School of Hygiene and Tropical Medicine
In house dust mite droppings there are 14 fully identified separate proteins that have the potential to cause an allergy, but first they must enter the body to be noticed. This entrance can be achieved thanks to the active digestive enzyme mentioned above that can 'melt-the-glue' that holds cells together. The breach creates an important entrance for another major mite allergen, the 'con-artist', known scientifically as Der p2. This allergen can trick the immune system into believing it's been attacked by bacteria causing further alarm. Beware, an established allergy to house dust mites can confuse and overwhelm a vulnerable immune system causing allergic diseases such as asthma, rhinitis and allergic dermatitis, also known as eczema.
Children are said to be most at risk from allergy to house dust mites, because they may think it's normal to always wheeze, sneeze or itch.
'Allergens and their role in the allergic immune response', TAE Platts-Mills, JA Woodfolk 'Immunological Reviews', 2011 Vol. 242: 51-68
'Dangerous Allergens: Why Some Allergens are Bad Actors'. Steve N. Georas, Fariba Rezace, Laurie Learner' Lisa Beck, 'Curr. Allergy Asthma Rep'. 2010; 10: 92-98
'CpG Motifs in bacterial DNA trigger direct B-cell activation'. Krieg, A.M. A.K. Yi, S. Matson, T.J. Waldschmidt, G.A. Bishop, R. Teasdale, G.A. Koretzky, and D.M. Klinman. 1995. 'Nature' (Lond.). 1995; 374: 546 - 549
'Is Permanent Parasitism Reversible? Critical Evidence from Early Evolution of House Dust Mites', Pavel B, Kilmov, Barry O'Connor, Oxford University Press Society of Systemic Biologists, Feb 13 2013