This review paper not only describes each T lymphocyte's responsibility, and the defence mechanisms they produce, but how they can also cause disease including allergy and are involved in some autoimmune diseases. The paper speculates on a fourth T lymphocyte as indicated in research. This 'phantom' lymphocyte appears as a combination of Th2/Th17, possibly a marker of sensitisation or in severe asthma. The major mite allergen Der p1- was referred to in this speculation. Confirmation is needed on Th2/Th17 existence.
Interesting quote from the paper, ' The main role of Th17 is their ability to recruit and activate neutrophil granulocytes, either directly through IL-8 production or indirectly by inducing the production of colony stimulatory factors (CSF) or CXCL8 by tissue resident cells.'
'Th 17 cells: new players in asthma pathogenesis', Cosmi L, Liotta F, Maggi E, Romagnani S, Annunziato, Allergy, 2011: John Wiley and Sons A/S DOI: 10.111/j.1398-9995.2011.02576.x.
'Dust Mites', Colloff M.J.(2009) CSIRO Publishing. Page 54