Thanks to the work of researchers the association of mite hypersensitivity with aspirin/NSAIDS intolerance has been clinically confirmed. However, what remains to be described is the connection between atopic allergy and non-allergic pathways. The paper names the foods implicated; the dust mite species associated with 'Pancake Syndrome'; describes the possible innate reactions involved; and identifies genetic factors that could be involved.
Foods (noted to date) Beignets, pizza dough, okonomi-yaki, polenta, flour-coated fish, scones and pancake mix. Pancakes are the most common food implicated in the reaction, hence the name.
Some of the allergic and innate immune responses mentioned are:
The author's abstract ends with: 'The association of mite hypersensitivity with aspirin NSAIDS intolerance has been confirmed and provides additional clues to various non-allergic pathways that may contribute to the acute and chronic inflammatory process observed in atopic, mite-allergic, individuals. The clinical relevance of these observations is presently under investigation'.
Perhaps under investigation is the possibility that inhibition of COX-1 isoenzyme, as seen in aspirin/NSAIDS hyper-reactivity, and the presence of COX-1 inhibitory substances in commercial house dust mite allergen extracts, may contribute to Pancake Syndrome. The possibility is discussed in this paper.
'Mite-induced inflammation: More than allergy', Sanchez-Borges M, Fernandez-Caldas E, Capriles-Hulett A, Caballero-Fonseca F, 'Allergy Rhinol' (Providence). 2012; 3 (1) e25-e29.
'Inhibition of human cyclooxygenase-1 by Dermatophagoides allergenic extracts'. Sanchez-Borges M, Owellet M, Percival M, et al, 'J. Allergy Clin. Immunol.', 115:S51, 2005